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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CLIC4 Antibody (aa1-50)   

CLIC4 Antibody (aa1-50)

Rabbit Polyclonal Antibody

     
  • WB - CLIC4 Antibody (aa1-50) ALS15120
    Western blot of extracts from HT-29 cells, using CLIC4 Antibody.
  • IHC - CLIC4 Antibody (aa1-50) ALS15120
    Anti-CLIC4 antibody IHC of human spleen.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9Y696
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 29kDa
Dilution ELISA (1:40000), IHC-P (10 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 25932
Other Names Chloride intracellular channel protein 4, Intracellular chloride ion channel protein p64H1, CLIC4
Target/Specificity CLIC4 Antibody detects endogenous levels of total CLIC4 protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsCLIC4 Antibody (aa1-50) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLIC4
Function Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell- surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical- basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane; Single-pass membrane protein. Nucleus matrix. Cell membrane; Single-pass membrane protein. Mitochondrion. Cell junction. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles
Tissue Location Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle
Volume 50 µl
Research Areas
Citations (0)

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Background

Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell- surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical- basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).

References

Edwards J.C.,et al.Am. J. Physiol. 276:F398-F408(1999).
Chuang J.Z.,et al.J. Neurosci. 19:2919-2928(1999).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Bienvenut W.V.,et al.Submitted (FEB-2006) to UniProtKB.
Berryman M.,et al.Mol. Biol. Cell 11:1509-1521(2000).

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$ 395.00
Cat# ALS15120
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