Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
SLC16A12 / MCT12 Antibody (aa115-164)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q6ZSM3 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 53kDa |
| Dilution | ELISA (1:20000), IHC-P (1:50-1:100), |
| Gene ID | 387700 |
|---|---|
| Other Names | Monocarboxylate transporter 12, MCT 12, Creatine transporter 2, CRT2, Solute carrier family 16 member 12, SLC16A12, MCT12 |
| Target/Specificity | MOT12 Antibody detects endogenous levels of total MOT12 protein. |
| Reconstitution & Storage | Store at -20°C for up to one year. |
| Precautions | SLC16A12 / MCT12 Antibody (aa115-164) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC16A12 (HGNC:23094) |
|---|---|
| Function | Functions as a transporter for creatine and as well for its precursor guanidinoacetate. Transport of creatine and GAA is independent of resting membrane potential and extracellular Na(+), Cl(-), or pH. Contributes to the process of creatine biosynthesis and distribution. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8BGC3}; Multi-pass membrane protein. Note=Interaction with isoform 2 of BSG is required for its localization to the plasma membrane. |
| Tissue Location | Most highly expressed in kidney, followed by retina, lung, heart and testis. Very weakly expressed in brain and liver. Also detected in lens. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Proton-linked monocarboxylate transporter that mediates creatine transport across the plasma membrane.
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 429:375-381(2004).
Kloeckener-Gruissem B.,et al.Am. J. Hum. Genet. 82:772-779(2008).
Abplanalp J.,et al.Hum. Mol. Genet. 22:3218-3226(2013).
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
