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SLC6A3 / Dopamine Transporter Antibody (EL2 Region)

Rabbit Polyclonal Antibody

     
  • WB - SLC6A3 / Dopamine Transporter Antibody (EL2 Region) ALS15133
    Western blot of human caudate lysate showing specific immunolabeling of the ~88k DAT protein.
    detail
  • IHC - SLC6A3 / Dopamine Transporter Antibody (EL2 Region) ALS15133
    Anti-SLC6A3 / Dopamine Transporter antibody IHC of human kidney.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IHC-Fr
Primary Accession Q01959
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 68kDa
Dilution IHC-Fr (1:1000), IHC-P (1:100), WB (1:1000)
Additional Information
Gene ID 6531
Other Names Sodium-dependent dopamine transporter, DA transporter, DAT, Solute carrier family 6 member 3, SLC6A3, DAT1
Target/Specificity Specific for the ~88k DAT protein in Western blots
Reconstitution & Storage Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
PrecautionsSLC6A3 / Dopamine Transporter Antibody (EL2 Region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC6A3
Synonyms DAT1
Function Mediates sodium- and chloride-dependent transport of dopamine (PubMed:1406597, PubMed:8302271, PubMed:10375632, PubMed:11093780, PubMed:15505207, PubMed:19478460). Also mediates sodium- and chloride- dependent transport of norepinephrine (also known as noradrenaline) (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein. Cell projection, neuron projection {ECO:0000250|UniProtKB:P23977}. Cell projection, axon. Note=Localizes to neurite tips in neuronal cells (By similarity). Colocalizes with SEPTIN4 at axon terminals, especially at the varicosities (By similarity) {ECO:0000250|UniProtKB:P23977, ECO:0000250|UniProtKB:Q61327}
Tissue Location Highly expressed in substantia nigra (PubMed:7637582). Expressed in axonal varicosities in dopaminergic nerve terminals (at protein level) (PubMed:17296554). Expressed in the striatum (at protein level) (PubMed:17296554)
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.

References

Vandenbergh D.J.,et al.Brain Res. Mol. Brain Res. 15:161-166(1992).
Giros B.,et al.Mol. Pharmacol. 42:383-390(1992).
Pristupa Z.B.,et al.Mol. Pharmacol. 45:125-135(1994).
Kawarai T.,et al.Gene 195:11-18(1997).
Vandenbergh D.J.,et al.Mol. Psychiatry 5:283-292(2000).

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Discontinued
Cat# ALS15133
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