|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:40000), IHC-P (10 µg/ml), WB (1:500-1:1000)|
|Other Names||Caspase-6, CASP-6, 18.104.22.168, Apoptotic protease Mch-2, Caspase-6 subunit p18, Caspase-6 subunit p11, CASP6, MCH2|
|Target/Specificity||Caspase 6 (Cleaved-Asp162) Antibody detects endogenous levels of fragment of activated Caspase 6 resulting from cleavage adjacent to Asp162.|
|Reconstitution & Storage||Store at -20°C for up to one year.|
|Precautions||CASP6 / Caspase 6 Antibody (aa130-179) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.|
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Provided below are standard protocols that you may find useful for product applications.
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
Fernandes-Alnemri T.,et al.Cancer Res. 55:2737-2742(1995).
Srinivasula S.M.,et al.J. Biol. Chem. 271:27099-27106(1996).
Bartke T.,et al.Mol. Cell 14:801-811(2004).
Suzuki A.,et al.Oncogene 23:7067-7075(2004).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
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