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IFT57 / HIPPI Antibody (Internal)

Goat Polyclonal Antibody

     
  • WB - IFT57 / HIPPI Antibody (Internal) ALS15149
    IFT57 antibody (1 ug/ml) staining of Mouse Brain lysate (35 ug protein/ml in RIPA buffer).
  • IHC - IFT57 / HIPPI Antibody (Internal) ALS15149
    Anti-IFT57 / HIPPI antibody IHC of human testis.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9NWB7
Reactivity Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Horse
Host Goat
Clonality Polyclonal
Calculated MW 49kDa
Dilution ELISA (1:8000), IHC-P (5 µg/ml), WB (1-3 µg/ml)
Additional Information
Gene ID 55081
Other Names Intraflagellar transport protein 57 homolog, Dermal papilla-derived protein 8, Estrogen-related receptor beta-like protein 1, HIP1-interacting protein, MHS4R2, IFT57, DERP8, ESRRBL1, HIPPI
Target/Specificity Human IFT57 / HIPPI.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsIFT57 / HIPPI Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IFT57
Synonyms DERP8, ESRRBL1, HIPPI
Function Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
Cellular Location Cytoplasm, cytoskeleton, cilium basal body. Note=Concentrates within the inner segment of cilia.
Tissue Location Present in many tissues such as brain, thymus, lymph node, lung, liver, skin and kidney (at protein level)
Volume 100 µl
Research Areas
Citations (0)

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Background

Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.

References

Gervais F.G.,et al.Nat. Cell Biol. 4:95-105(2002).
Pasutto F.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
Ikeda A.,et al.Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS15149
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