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IFT57 / HIPPI Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9NWB7 |
| Reactivity | Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Horse |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 49kDa |
| Dilution | ELISA (1:8000), IHC-P (5 µg/ml), WB (1-3 µg/ml) |
| Gene ID | 55081 |
|---|---|
| Other Names | Intraflagellar transport protein 57 homolog, Dermal papilla-derived protein 8, Estrogen-related receptor beta-like protein 1, HIP1-interacting protein, MHS4R2, IFT57, DERP8, ESRRBL1, HIPPI |
| Target/Specificity | Human IFT57 / HIPPI. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | IFT57 / HIPPI Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IFT57 |
|---|---|
| Synonyms | DERP8, ESRRBL1, HIPPI |
| Function | Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'- AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. |
| Cellular Location | Cell projection, cilium {ECO:0000250|UniProtKB:Q8BXG3}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q5EA95}. Note=Concentrates within the inner segment of cilia. |
| Tissue Location | Present in many tissues such as brain, thymus, lymph node, lung, liver, skin and kidney (at protein level) |
| Volume | 100 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
References
Gervais F.G.,et al.Nat. Cell Biol. 4:95-105(2002).
Pasutto F.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
Ikeda A.,et al.Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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