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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   HDAC4 Antibody   

HDAC4 Antibody

Rabbit Polyclonal Antibody

     
  • IHC - HDAC4 Antibody ALS15151
    Anti-HDAC4 antibody IHC of human pancreas.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P56524
Reactivity Human, Chicken
Host Rabbit
Clonality Polyclonal
Calculated MW 119kDa
Dilution IHC-P (5 µg/ml), WB (0.5-4 µg/ml),
Additional Information
Gene ID 9759
Other Names Histone deacetylase 4, HD4, 3.5.1.98, HDAC4, KIAA0288
Target/Specificity The antibody detects ~140 kD human HDAC-4. Reactivity to other species has not been determined.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsHDAC4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HDAC4
Synonyms KIAA0288
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Cellular Location Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation
Tissue Location Ubiquitous.
Volume 100 µl
Research Areas
Citations (0)

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Background

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

References

Grozinger C.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:4868-4873(1999).
Ohara O.,et al.DNA Res. 4:53-59(1997).
Ohara O.,et al.Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS15151
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