|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||ELISA (1:10000-1:80000), IHC-P (1:100), WB (1:200-1:1000)|
|Other Names||Keratin, type II cytoskeletal 1, 67 kDa cytokeratin, Cytokeratin-1, CK-1, Hair alpha protein, Keratin-1, K1, Type-II keratin Kb1, KRT1, KRTA|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||KRT1 / CK1 / Cytokeratin 1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK.|
|Cellular Location||Cell membrane. Note=Located on plasma membrane of neuroblastoma NMB7 cells|
|Tissue Location||The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis|
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May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK.
Johnson L.D.,et al.Proc. Natl. Acad. Sci. U.S.A. 82:1896-1900(1985).
Whittock N.V.,et al.Biochem. Biophys. Res. Commun. 274:149-152(2000).
Hatsell S.J.,et al.J. Invest. Dermatol. 116:606-609(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
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