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BCAR3 Antibody

Rabbit Polyclonal Antibody

     
  • IHC - BCAR3 Antibody ALS15164
    Anti-BCAR3 antibody IHC of human liver.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession O75815
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 93kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 8412
Other Names Breast cancer anti-estrogen resistance protein 3, Novel SH2-containing protein 2, SH2 domain-containing protein 3B, BCAR3, NSP2, SH2D3B
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsBCAR3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BCAR3
Synonyms NSP2, SH2D3B
Function May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins.
Tissue Location Ubiquitously expressed. Found in several cancer cell lines, but not in nonmalignant breast tissue
Citations (0)

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Background

May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins.

References

van Agthoven T.,et al.EMBO J. 17:2799-2808(1998).
Lu Y.,et al.J. Biol. Chem. 274:10047-10052(1999).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Gregory S.G.,et al.Nature 441:315-321(2006).

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$ 395.00
Cat# ALS15164
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