|Dilution||IHC-P (5 µg/ml)|
|Other Names||Breast cancer anti-estrogen resistance protein 3, Novel SH2-containing protein 2, SH2 domain-containing protein 3B, BCAR3, NSP2, SH2D3B|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||BCAR3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins.|
|Tissue Location||Ubiquitously expressed. Found in several cancer cell lines, but not in nonmalignant breast tissue|
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May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins.
van Agthoven T.,et al.EMBO J. 17:2799-2808(1998).
Lu Y.,et al.J. Biol. Chem. 274:10047-10052(1999).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Gregory S.G.,et al.Nature 441:315-321(2006).
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