SERF1A / SERF1 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
---|---|
Primary Accession | O75920 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 12349 Da |
Dilution | IHC-P (10 µg/ml) |
Gene ID | 728492;8293 |
---|---|
Other Names | Small EDRK-rich factor 1, Protein 4F5, h4F5, SMA modifier 1, SERF1A, FAM2A, SERF1, SMAM1 |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
Precautions | SERF1A / SERF1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SERF1A |
---|---|
Synonyms | FAM2A, SERF1, SMAM1 |
Function | Positive regulator of amyloid protein aggregation and proteotoxicity (PubMed:20723760, PubMed:22854022, PubMed:31034892). Induces conformational changes in amyloid proteins, such as APP, HTT, and SNCA, driving them into compact formations preceding the formation of aggregates (PubMed:20723760, PubMed:22854022, PubMed:31034892). |
Cellular Location | Cytoplasm, cytosol. Nucleus |
Tissue Location | Isoform Long is predominantly expressed in heart, brain and skeletal muscle. Isoform Short and Isoform Long are expressed throughout the central nervous system, including spinal cord |
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