|Application ||IHC-P, IF|
|Dilution||IHC-P (5 µg/ml)|
|Other Names||Amyloid beta A4 precursor protein-binding family A member 1, Adapter protein X11alpha, Neuron-specific X11 protein, Neuronal Munc18-1-interacting protein 1, Mint-1, APBA1, MINT1, X11|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||APBA1 / MINT1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta- amyloid precursor protein (APP) and hence formation of beta-APP.|
|Cellular Location||Cytoplasm. Cytoplasm, perinuclear region Nucleus. Note=Only about 5% of the protein is located in the nucleus|
|Tissue Location||Brain and spinal cord. Isoform 2 is expressed in testis and brain, but not detected in lung, liver or spleen|
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Provided below are standard protocols that you may find useful for product applications.
Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta- amyloid precursor protein (APP) and hence formation of beta-APP.
Okamoto M.,et al.J. Biol. Chem. 272:31459-31464(1997).
Borg J.-P.,et al.J. Biol. Chem. 273:14761-14766(1998).
Humphray S.J.,et al.Nature 429:369-374(2004).
Duclos F.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:109-113(1993).
Borg J.-P.,et al.Mol. Cell. Biol. 16:6229-6241(1996).
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