APBA1 / MINT1 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, IF |
---|---|
Primary Accession | Q02410 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 93kDa |
Dilution | IHC-P (5 µg/ml) |
Gene ID | 320 |
---|---|
Other Names | Amyloid beta A4 precursor protein-binding family A member 1, Adapter protein X11alpha, Neuron-specific X11 protein, Neuronal Munc18-1-interacting protein 1, Mint-1, APBA1, MINT1, X11 |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
Precautions | APBA1 / MINT1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | APBA1 |
---|---|
Synonyms | MINT1, X11 |
Function | Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. Component of the LIN-10- LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). |
Cellular Location | Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Only about 5% of the protein is located in the nucleus |
Tissue Location | Brain and spinal cord. Isoform 2 is expressed in testis and brain, but not detected in lung, liver or spleen |
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Provided below are standard protocols that you may find useful for product applications.
Background
Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta- amyloid precursor protein (APP) and hence formation of beta-APP.
References
Okamoto M.,et al.J. Biol. Chem. 272:31459-31464(1997).
Borg J.-P.,et al.J. Biol. Chem. 273:14761-14766(1998).
Humphray S.J.,et al.Nature 429:369-374(2004).
Duclos F.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:109-113(1993).
Borg J.-P.,et al.Mol. Cell. Biol. 16:6229-6241(1996).
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