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SNCG / Gamma-Synuclein Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | O76070 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 13kDa |
| Dilution | IHC-P (1:200), WB (1:2000), |
| Gene ID | 6623 |
|---|---|
| Other Names | Gamma-synuclein, Breast cancer-specific gene 1 protein, Persyn, Synoretin, SR, SNCG, BCSG1, PERSYN, PRSN |
| Reconstitution & Storage | Long term: -20°C; Short term: -20°C |
| Precautions | SNCG / Gamma-Synuclein Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SNCG |
|---|---|
| Synonyms | BCSG1, PERSYN, PRSN |
| Function | Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity). |
| Cellular Location | Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle |
| Tissue Location | Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).
References
Ji H.,et al.Cancer Res. 57:759-764(1997).
Ninkina N.N.,et al.Hum. Mol. Genet. 7:1417-1424(1998).
Lavedan C.,et al.Hum. Genet. 103:106-112(1998).
Han C.,et al.Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
Pronin A.N.,et al.J. Biol. Chem. 275:26515-26522(2000).
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