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CNOT4 / CLONE243 Antibody (aa50-100)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | O95628 |
| Reactivity | Human, Mouse, Rat, Chicken, Xenopus, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 64kDa |
| Dilution | IHC-P (10 µg/ml), WB (0.05-0.1 µg/ml), |
| Gene ID | 4850 |
|---|---|
| Other Names | CCR4-NOT transcription complex subunit 4, 6.3.2.-, CCR4-associated factor 4, E3 ubiquitin-protein ligase CNOT4, Potential transcriptional repressor NOT4Hp, CNOT4, NOT4 |
| Target/Specificity | Human CNOT4 |
| Reconstitution & Storage | Long term: -20°C; Short term: -20°C |
| Precautions | CNOT4 / CLONE243 Antibody (aa50-100) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CNOT4 |
|---|---|
| Synonyms | NOT4 |
| Function | Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins (PubMed:11823428, PubMed:22159038, PubMed:26575292). Involved in activation of the JAK/STAT pathway (PubMed:11823428, PubMed:22159038). Catalyzes ubiquitination of methylated RBM15 (PubMed:26575292). Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391). As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy (PubMed:29861391). |
| Cellular Location | Cytoplasm. Nucleus. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Has E3 ubiquitin ligase activity. Involved in activation of the JAK/STAT pathway.
References
Chiang P.-W.,et al.Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
Albert T.K.,et al.Nucleic Acids Res. 28:809-817(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 424:157-164(2003).
Barrow I.K.-P.,et al.Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
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