|Application ||WB, IHC-P, IF, E|
|Dilution||ELISA (1:1000), IF (1:100-1:500), IHC-P (2.5 µg/ml), WB (1:500-1:1000) ,|
|Other Names||Endothelin-1 receptor, Endothelin A receptor, ET-A, ETA-R, hET-AR, EDNRA, ETA, ETRA|
|Target/Specificity||EDNRA Antibody detects endogenous levels of total EDNRA protein.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||EDNRA / Endothelin A Receptor Antibody (aa378-427) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
Adachi M.,et al.Biochem. Biophys. Res. Commun. 180:1265-1272(1991).
Cyr C.,et al.Biochem. Biophys. Res. Commun. 181:184-190(1991).
Hosoda K.,et al.FEBS Lett. 287:23-26(1991).
Arai H.,et al.Jpn. Circ. J. 56:1303-1307(1992).
Elshourbagy N.A.,et al.J. Biol. Chem. 268:3873-3879(1993).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.