|Application ||WB, IHC-P|
|Dilution||IHC-P (10 µg/ml), WB (1-3 µg/ml),|
|Other Names||Transcription factor GATA-4, GATA-binding factor 4, GATA4|
|Reconstitution & Storage||Store at 4°C for short term applications. For long term storage, aliquot and store at -20°C.|
|Precautions||GATA4 Antibody (aa330-380) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (PubMed:24000169). Involved in bone morphogenetic protein (BMP)- mediated induction of cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (PubMed:20081228). Required during testicular development (PubMed:21220346). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (PubMed:15734735).|
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Provided below are standard protocols that you may find useful for product applications.
Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes cardiac myocyte enlargement. Required during testicular development.
Huang W.Y.,et al.Gene 155:219-223(1995).
Palaszewski I.,et al.Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
Nusbaum C.,et al.Nature 439:331-335(2006).
Gauci S.,et al.Anal. Chem. 81:4493-4501(2009).
Sunagawa Y.,et al.J. Biol. Chem. 285:9556-9568(2010).
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