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GATA4 Antibody (aa330-380)

Rabbit Polyclonal Antibody

     
  • WB - GATA4 Antibody (aa330-380) ALS15276
    Western blot of GATA-4 in human kidney lysate in the 1) absence and 2) presence of immunizing...
  • IHC - GATA4 Antibody (aa330-380) ALS15276
    Anti-GATA4 antibody IHC of human brain, cortex.
  • IHC - GATA4 Antibody (aa330-380) ALS15276
    Anti-GATA4 antibody IHC of human prostate.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P43694
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 45kDa
Dilution IHC-P (10 µg/ml), WB (1-3 µg/ml),
Additional Information
Gene ID 2626
Other Names Transcription factor GATA-4, GATA-binding factor 4, GATA4
Target/Specificity Human GATA4
Reconstitution & Storage Store at 4°C for short term applications. For long term storage, aliquot and store at -20°C.
PrecautionsGATA4 Antibody (aa330-380) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GATA4
Function Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (PubMed:24000169). Involved in bone morphogenetic protein (BMP)- mediated induction of cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (PubMed:20081228). Required during testicular development (PubMed:21220346). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (PubMed:15734735).
Cellular Location Nucleus
Research Areas
Citations (0)

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Background

Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes cardiac myocyte enlargement. Required during testicular development.

References

Huang W.Y.,et al.Gene 155:219-223(1995).
Palaszewski I.,et al.Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
Nusbaum C.,et al.Nature 439:331-335(2006).
Gauci S.,et al.Anal. Chem. 81:4493-4501(2009).
Sunagawa Y.,et al.J. Biol. Chem. 285:9556-9568(2010).

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$ 395.00
Cat# ALS15276
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