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FLII / FLI Antibody (aa90-140)

Rabbit Polyclonal Antibody

     
  • IHC - FLII / FLI Antibody (aa90-140) ALS15278
    Anti-FLII / FLI antibody IHC of human heart.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q13045
Reactivity Human, Mouse, Rat, Monkey, Horse
Host Rabbit
Clonality Polyclonal
Calculated MW 145kDa
Dilution IHC-P (5-10 µg/ml)
Additional Information
Gene ID 2314
Other Names Protein flightless-1 homolog, FLII, FLIL
Target/Specificity Human FLII
Reconstitution & Storage Store at 4°C, stable for 6 months. For long term storage, aliquot and store at -20°C.
PrecautionsFLII / FLI Antibody (aa90-140) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FLII
Synonyms FLIL
Function May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation.
Cellular Location Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, focal adhesion. Note=Colocalizes to actin-rich structures in blastocysts and, together with HRAS, RHOA and CDC42, in migrating fibroblasts. Localizes to centrosomes (By similarity)
Tissue Location Strongest expression in skeletal muscle with high expression also in the heart and lung
Research Areas
Citations (0)

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Background

May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation.

References

Campbell H.D.,et al.Genomics 42:46-54(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Gevaert K.,et al.Nat. Biotechnol. 21:566-569(2003).
Campbell H.D.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:11386-11390(1993).

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$ 395.00
Cat# ALS15278
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