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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LAT Antibody (aa70-120)   

LAT Antibody (aa70-120)

Rabbit Polyclonal Antibody

     
  • WB - LAT Antibody (aa70-120) ALS15292
    Western blot of LAT in mouse thymus tissue lysate in the 1) absence and 2) presence of...
  • IHC - LAT Antibody (aa70-120) ALS15292
    Anti-LAT1 / LAT antibody IHC of human small intestine.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession O43561
Reactivity Human, Mouse, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 28kDa
Dilution IHC-P (10 µg/ml), WB (1-3 µg/ml),
Additional Information
Gene ID 27040
Other Names Linker for activation of T-cells family member 1, 36 kDa phospho-tyrosine adapter protein, pp36, p36-38, LAT
Target/Specificity Human LAT
Reconstitution & Storage Store at 4°C for short term applications. For long term storage, aliquot and store at -20°C.
PrecautionsLAT Antibody (aa70-120) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LAT
Function Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
Cellular Location Cell membrane; Single-pass type III membrane protein Note=Present in lipid rafts
Tissue Location Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).
Research Areas
Citations (0)

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Background

Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

References

Zhang W.,et al.Cell 92:83-92(1998).
Weber J.R.,et al.J. Exp. Med. 187:1157-1161(1998).
Muschen M.,et al.Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
Martin J.,et al.Nature 432:988-994(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS15292
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