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SDCBP / Syntenin Antibody (N-Terminus)

Goat Polyclonal Antibody

     
  • WB - SDCBP / Syntenin Antibody (N-Terminus) ALS15303
    Antibody (0.01 ug/ml) staining of Human HEK293 cell lysate (35 ug protein in RIPA buffer).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O00560
Reactivity Human, Mouse, Rat, Hamster, Monkey, Pig, Chicken, Horse, Xenopus, Bovine
Host Goat
Clonality Polyclonal
Calculated MW 32kDa
Dilution ELISA (1:128000), IHC-P (10 µg/ml), WB (0.01-0.03 µg/ml)
Additional Information
Gene ID 6386
Other Names Syntenin-1, Melanoma differentiation-associated protein 9, MDA-9, Pro-TGF-alpha cytoplasmic domain-interacting protein 18, TACIP18, Scaffold protein Pbp1, Syndecan-binding protein 1, SDCBP, MDA9, SYCL
Target/Specificity Human SDCBP / Syntenin. This antibody is expected to recognise isoform 1 (NP_005616.2 and NP_001007068.1) and isoform 3 (NP_001007070.1and NP_001007071.1) only.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsSDCBP / Syntenin Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SDCBP
Synonyms MDA9, SYCL
Function Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1- mediated SMAD2/3 activation and TGFB1-induced epithelial-to- mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395).
Cellular Location Cell junction, focal adhesion. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus. Melanosome Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Secreted, exosome. Membrane raft. Note=Mainly membrane-associated Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Tissue Location Expressed in lung cancers, including adenocarcinoma, squamous cell carcinoma and small-cell carcinoma (at protein level) (PubMed:25893292). Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta.
Research Areas
Citations (0)

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Background

Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.

References

Lin J.J.,et al.Mol. Cell. Differ. 4:317-333(1996).
Grootjans J.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:13683-13688(1997).
Burbelo P.D.,et al.Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
Lin J.J.,et al.Gene 207:105-110(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS15303
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