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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   MYL2 Antibody (clone 7C9)   

MYL2 Antibody (clone 7C9)

Mouse Monoclonal Antibody

     
  • IHC - MYL2 Antibody (clone 7C9) ALS15307
    Anti-MYL2 antibody IHC of human heart.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P10916
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 7C9
Calculated MW 19kDa
Dilution ELISA (1:10000), IHC-P (1:100), WB (1:500-1:2000)
Additional Information
Gene ID 4633
Other Names Myosin regulatory light chain 2, ventricular/cardiac muscle isoform, MLC-2, MLC-2v, MYL2
Target/Specificity Human MYL2
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsMYL2 Antibody (clone 7C9) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MYL2 (HGNC:7583)
Function Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity).
Cellular Location Cytoplasm, myofibril, sarcomere, A band {ECO:0000250|UniProtKB:P08733}
Research Areas
Citations (0)

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References

Libera L.D.,et al.Nucleic Acids Res. 17:2360-2360(1989).
Wu Q.L.,et al.Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
Margossian S.S.,et al.Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
Wadgaonkar R.,et al.Cell. Mol. Biol. Res. 39:13-26(1993).
Kovalyov L.I.,et al.Electrophoresis 16:1160-1169(1995).

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$ 395.00
Cat# ALS15307
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