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CBX4 Antibody

Rabbit Polyclonal Antibody

     
  • IHC - CBX4 Antibody ALS15315
    Anti-HPC2 / CBX4 antibody IHC of human brain, cortex neurons.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O00257
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 61kDa
Dilution ELISA (1:10000), IHC-P (5 µg/ml), WB (1:250)
Additional Information
Gene ID 8535
Other Names E3 SUMO-protein ligase CBX4, 6.3.2.-, Chromobox protein homolog 4, Polycomb 2 homolog, Pc2, hPc2, CBX4
Target/Specificity Not tested with other proteins.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsCBX4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CBX4
Function E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131.
Cellular Location Nucleus. Nucleus speckle. Note=Localization to nuclear polycomb bodies is required for ZNF131 sumoylation (PubMed:22467880)
Tissue Location Ubiquitous.
Citations (0)

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Background

E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131.

References

Satijn D.P.E.,et al.Mol. Cell. Biol. 17:6076-6086(1997).
Salichs E.,et al.PLoS Genet. 5:E1000397-E1000397(2009).
Liu M.,et al.Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
Zody M.C.,et al.Nature 440:1045-1049(2006).
Satijn D.P.E.,et al.Mol. Cell. Biol. 17:4105-4113(1997).

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$ 395.00
Cat# ALS15315
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