|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:10000), IHC-P (5 µg/ml), WB (1:250)|
|Other Names||E3 SUMO-protein ligase CBX4, 6.3.2.-, Chromobox protein homolog 4, Polycomb 2 homolog, Pc2, hPc2, CBX4|
|Target/Specificity||Not tested with other proteins.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||CBX4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131.|
|Cellular Location||Nucleus. Nucleus speckle. Note=Localization to nuclear polycomb bodies is required for ZNF131 sumoylation (PubMed:22467880)|
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Provided below are standard protocols that you may find useful for product applications.
E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131.
Satijn D.P.E.,et al.Mol. Cell. Biol. 17:6076-6086(1997).
Salichs E.,et al.PLoS Genet. 5:E1000397-E1000397(2009).
Liu M.,et al.Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
Zody M.C.,et al.Nature 440:1045-1049(2006).
Satijn D.P.E.,et al.Mol. Cell. Biol. 17:4105-4113(1997).
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