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CBX4 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | O00257 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 61kDa |
| Dilution | ELISA (1:10000), IHC-P (5 µg/ml), WB (1:250) |
| Gene ID | 8535 |
|---|---|
| Other Names | E3 SUMO-protein ligase CBX4, 6.3.2.-, Chromobox protein homolog 4, Polycomb 2 homolog, Pc2, hPc2, CBX4 |
| Target/Specificity | Not tested with other proteins. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | CBX4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CBX4 |
|---|---|
| Function | E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I (PubMed:12679040). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850). |
| Cellular Location | Nucleus. Nucleus speckle. Note=Localization to nuclear polycomb bodies is required for ZNF131 sumoylation (PubMed:22467880). Localized in distinct foci on chromatin (PubMed:18927235) |
| Tissue Location | Ubiquitous. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131.
References
Satijn D.P.E.,et al.Mol. Cell. Biol. 17:6076-6086(1997).
Salichs E.,et al.PLoS Genet. 5:E1000397-E1000397(2009).
Liu M.,et al.Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
Zody M.C.,et al.Nature 440:1045-1049(2006).
Satijn D.P.E.,et al.Mol. Cell. Biol. 17:4105-4113(1997).
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