TRPC5 Antibody (clone S67-15)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, ICC |
---|---|
Primary Accession | Q9UL62 |
Reactivity | Human, Mouse, Rat |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | S67-15 |
Calculated MW | 111kDa |
Dilution | IHC-P (5 µg/ml) |
Gene ID | 7224 |
---|---|
Other Names | Short transient receptor potential channel 5, TrpC5, Transient receptor protein 5, TRP-5, hTRP-5, hTRP5, TRPC5, TRP5 |
Target/Specificity | ~110kDa. |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
Precautions | TRPC5 Antibody (clone S67-15) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TRPC5 |
---|---|
Synonyms | TRP5 |
Function | Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity). |
Cellular Location | Cell membrane; Multi-pass membrane protein |
Tissue Location | Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole |
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Provided below are standard protocols that you may find useful for product applications.
Background
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion.
References
Sossey-Alaoui K.,et al.Genomics 60:330-340(1999).
Ross M.T.,et al.Nature 434:325-337(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Philipp S.,et al.EMBO J. 17:4274-4282(1998).
Hofmann T.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:7461-7466(2002).
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