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TRPC5 Antibody (clone S67-15)

Mouse Monoclonal Antibody

     
  • IHC - TRPC5 Antibody (clone S67-15) ALS15322
    Anti-TRPC5 antibody IHC of human brain, cortex.
    detail
  • IHC - TRPC5 Antibody (clone S67-15) ALS15322
    Anti-TRPC5 antibody IHC of human brain, cerebellum.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC
Primary Accession Q9UL62
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Clone Names S67-15
Calculated MW 111kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 7224
Other Names Short transient receptor potential channel 5, TrpC5, Transient receptor protein 5, TRP-5, hTRP-5, hTRP5, TRPC5, TRP5
Target/Specificity ~110kDa.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsTRPC5 Antibody (clone S67-15) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRPC5
Synonyms TRP5
Function Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole
Research Areas
Citations (0)
citation

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Background

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion.

References

Sossey-Alaoui K.,et al.Genomics 60:330-340(1999).
Ross M.T.,et al.Nature 434:325-337(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Philipp S.,et al.EMBO J. 17:4274-4282(1998).
Hofmann T.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:7461-7466(2002).

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Discontinued
Cat# ALS15322
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