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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   KCNAB1 Antibody (clone S47-42)   

KCNAB1 Antibody (clone S47-42)

Mouse Monoclonal Antibody

  • IHC - KCNAB1 Antibody (clone S47-42) ALS15324
    Anti-KCNAB1 antibody IHC of human heart.
  • IHC - KCNAB1 Antibody (clone S47-42) ALS15324
    Anti-KCNAB1 antibody IHC of human pancreas.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14722
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Clone Names S47-42
Calculated MW 47kDa
Dilution IHC-P (10 µg/ml), WB (1 µg/ml),
Additional Information
Gene ID 7881
Other Names Voltage-gated potassium channel subunit beta-1, K(+) channel subunit beta-1, Kv-beta-1, KCNAB1, KCNA1B
Target/Specificity Detects ~65kDa.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsKCNAB1 Antibody (clone S47-42) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KCNA1B
Function Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7499366, PubMed:7603988, PubMed:17156368,PubMed:17540341, PubMed:19713757). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757). Accelerates KCNA4 channel closure (PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (PubMed:17156368). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity). Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1 (PubMed:7890032, PubMed:7890764). Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity (PubMed:17540341). Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity).
Cellular Location Cytoplasm. Membrane {ECO:0000250|UniProtKB:P63144}; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits.
Tissue Location In brain, expression is most prominent in caudate nucleus, hippocampus and thalamus. Significant expression also detected in amygdala and subthalamic nucleus. Also expressed in both healthy and cardiomyopathic heart. Up to four times more abundant in left ventricle than left atrium
Research Areas
Citations (0)

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Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. All three isoforms alter the functional properties of Kv1.4 and Kv1.5. Isoform KvB1.2 has no effect on Kv1.1, Kv1.2 or Kv2.1.


England S.K.,et al.J. Biol. Chem. 270:28531-28534(1995).
Majumder K.,et al.FEBS Lett. 361:13-16(1995).
England S.K.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:6309-6313(1995).
Mccormack K.,et al.FEBS Lett. 370:32-36(1995).
Leicher T.,et al.Neuropharmacology 35:787-795(1996).

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$ 395.00
Cat# ALS15324
Availability: 5 days
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