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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CASK Antibody (clone S56A-50)   

CASK Antibody (clone S56A-50)

Mouse Monoclonal Antibody

     
  • IHC - CASK Antibody (clone S56A-50) ALS15325
    Anti-CASK antibody IHC of human brain, cortex.
  • IHC - CASK Antibody (clone S56A-50) ALS15325
    Anti-CASK antibody IHC of human kidney.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IP
Primary Accession O14936
Reactivity Human, Mouse, Rat, Zebrafish, Xenopus
Host Mouse
Clonality Monoclonal
Clone Names S56A-50
Calculated MW 105kDa
Dilution IHC-P (5 µg/ml), WB (1:1000),
Additional Information
Gene ID 8573
Other Names Peripheral plasma membrane protein CASK, hCASK, 2.7.11.1, Calcium/calmodulin-dependent serine protein kinase, Protein lin-2 homolog, CASK, LIN2
Target/Specificity Detects ~100kDa.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsCASK Antibody (clone S56A-50) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CASK
Synonyms LIN2
Function Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.
Cellular Location Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein
Tissue Location Ubiquitous. Expression is significantly greater in brain relative to kidney, lung, and liver and in fetal brain and kidney relative to lung and liver
Research Areas
Citations (0)

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Background

Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.

References

Cohen A.R.,et al.J. Cell Biol. 142:129-138(1998).
Zha D.,et al.Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
Ding L.,et al.Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
Yan Y.,et al.Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
Ross M.T.,et al.Nature 434:325-337(2005).

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$ 395.00
Cat# ALS15325
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