|Application ||WB, IHC-P, IP|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (5 µg/ml)|
|Other Names||Wiskott-Aldrich syndrome protein family member 1, WASP family protein member 1, Protein WAVE-1, Verprolin homology domain-containing protein 1, WASF1, KIAA0269, SCAR1, WAVE1|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||WASF1 / WAVE Antibody (clone S91-36) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0269, SCAR1, WAVE1|
|Function||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell junction, synapse. Note=Dot-like pattern in the cytoplasm Concentrated in Rac-regulated membrane-ruffling areas|
|Tissue Location||Highly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood|
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Provided below are standard protocols that you may find useful for product applications.
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
Bear J.E.,et al.J. Cell Biol. 142:1325-1335(1998).
Nagase T.,et al.DNA Res. 3:321-329(1996).
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Machesky L.M.,et al.Curr. Biol. 8:1347-1356(1998).
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