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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   WASF1 / WAVE Antibody (clone S91-36)   

WASF1 / WAVE Antibody (clone S91-36)

Mouse Monoclonal Antibody

     
  • IHC - WASF1 / WAVE Antibody (clone S91-36) ALS15327
    Anti-WASF1 / WAVE antibody IHC of human liver.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IP
Primary Accession Q92558
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Clone Names S91-36
Calculated MW 62kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 8936
Other Names Wiskott-Aldrich syndrome protein family member 1, WASP family protein member 1, Protein WAVE-1, Verprolin homology domain-containing protein 1, WASF1, KIAA0269, SCAR1, WAVE1
Target/Specificity 75kD.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsWASF1 / WAVE Antibody (clone S91-36) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name WASF1
Synonyms KIAA0269, SCAR1, WAVE1
Function Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
Cellular Location Cytoplasm, cytoskeleton. Cell junction, synapse {ECO:0000250|UniProtKB:Q5BJU7}. Cell junction, focal adhesion. Note=Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas (PubMed:9889097). Partial translocation to focal adhesion sites might be mediated by interaction with SORBS2 (PubMed:18559503)
Tissue Location Highly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood
Research Areas
Citations (0)

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Background

Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.

References

Bear J.E.,et al.J. Cell Biol. 142:1325-1335(1998).
Nagase T.,et al.DNA Res. 3:321-329(1996).
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Machesky L.M.,et al.Curr. Biol. 8:1347-1356(1998).

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$ 395.00
Cat# ALS15327
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