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ITPR1 / IP3 Receptor Type 1 Antibody (clone S24-18)

Mouse Monoclonal Antibody

     
  • IHC - ITPR1 / IP3 Receptor Type 1 Antibody (clone S24-18) ALS15328
    Anti-IP3R1 / IP3R antibody IHC of human brain, cerebellum, Purkinje.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IP
Primary Accession Q14643
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Clone Names S24-18
Calculated MW 314kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 3708
Other Names Inositol 1, 4, 5-trisphosphate receptor type 1, IP3 receptor isoform 1, IP3R 1, InsP3R1, Type 1 inositol 1, 4, 5-trisphosphate receptor, Type 1 InsP3 receptor, ITPR1, INSP3R1
Target/Specificity Detects ~300kDa. Does notrecognize type 2 and type 3IP3R's.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsITPR1 / IP3 Receptor Type 1 Antibody (clone S24-18) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ITPR1
Synonyms INSP3R1
Function Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate (PubMed:27108797). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q9TU34}; Multi-pass membrane protein. Cytoplasm, perinuclear region. Note=Endoplasmic reticulum and secretory granules (By similarity) {ECO:0000250|UniProtKB:Q9TU34}
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Background

Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).

References

Yamada N.,et al.Biochem. J. 302:781-790(1994).
Harnick D.J.,et al.J. Biol. Chem. 270:2833-2840(1995).
Marks A.,et al.Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
Nucifora F.C. Jr.,et al.Brain Res. Mol. Brain Res. 32:291-296(1995).
Muzny D.M.,et al.Nature 440:1194-1198(2006).

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$ 395.00
Cat# ALS15328
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