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MNK / ATP7A Antibody (clone S60-4)

Mouse Monoclonal Antibody

     
  • IHC - MNK / ATP7A Antibody (clone S60-4) ALS15329
    Anti-MNK / ATP7A antibody IHC of human small intestine.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IP
Primary Accession Q04656
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Clone Names S60-4
Calculated MW 163kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 538
Other Names Copper-transporting ATPase 1, 3.6.3.54, Copper pump 1, Menkes disease-associated protein, ATP7A, MC1, MNK
Target/Specificity Detects ~180kDa in rat brainmembrane preparations.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsMNK / ATP7A Antibody (clone S60-4) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATP7A
Synonyms MC1, MNK
Function May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells.
Cellular Location Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Cycles constitutively between the trans-Golgi network (TGN) and the plasma membrane (PubMed:9147644) Predominantly found in the TGN and relocalized to the plasma membrane in response to elevated copper levels Isoform 5: Endoplasmic reticulum
Tissue Location Found in most tissues except liver. Isoform 3 is widely expressed including in liver cell lines. Isoform 1 is expressed in fibroblasts, choriocarcinoma, colon carcinoma and neuroblastoma cell lines. Isoform 2 is expressed in fibroblasts, colon carcinoma and neuroblastoma cell lines
Research Areas
Citations (0)

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Background

May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells.

References

Vulpe C.D.,et al.Nat. Genet. 3:7-13(1993).
Vulpe C.D.,et al.Nat. Genet. 3:273-273(1993).
Tuemer Z.,et al.Genomics 26:437-442(1995).
Reddy M.C.,et al.Biochem. J. 334:71-77(1998).
Harris E.D.,et al.Adv. Exp. Med. Biol. 448:39-51(1999).

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$ 395.00
Cat# ALS15329
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