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AQP3 / Aquaporin 3 Antibody

Rabbit Polyclonal Antibody

     
  • IF - AQP3 / Aquaporin 3 Antibody ALS15342
    IF analysis of Aquaporin 3 in rat kidney tissues using a 1 in 200 dilution of AQP3 / Aquaporin 3...
  • IHC - AQP3 / Aquaporin 3 Antibody ALS15342
    Anti-AQP3 / Aquaporin 3 antibody IHC of human kidney.
  • IHC - AQP3 / Aquaporin 3 Antibody ALS15342
    Anti-AQP3 / Aquaporin 3 antibody IHC of human prostate.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession Q92482
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 32kDa
Dilution IF (1:200-1:400), IHC-P (10 µg/ml), WB (1:1000-1:4000)
Additional Information
Gene ID 360
Other Names Aquaporin-3, AQP-3, Aquaglyceroporin-3, AQP3
Target/Specificity Detects ~31.5kDa.Glycosylated bands ~35-50kDa.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsAQP3 / Aquaporin 3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AQP3
Function Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).
Cellular Location Basolateral cell membrane; Multi-pass membrane protein. Note=In collecting ducts of kidney
Tissue Location Widely expressed in epithelial cells of kidney (collecting ducts) and airways, in keratinocytes, immature dendritic cells and erythrocytes. Isoform 2 is not detectable in erythrocytes at the protein level
Volume 500 µl
Research Areas
Citations (0)

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Background

Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).

References

Ishibashi K.,et al.Genomics 27:352-354(1995).
Ishibashi K.,et al.Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
Roudier N.,et al.J. Biol. Chem. 277:45854-45859(2002).
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS15342
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