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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   BRUCE / BIRC6 Antibody (C-Terminus)   

BRUCE / BIRC6 Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • IHC - BRUCE / BIRC6 Antibody (C-Terminus) ALS15353
    Anti-BRUCE / BIRC6 antibody IHC of human lung, respiratory epithelium.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession Q9NR09
Reactivity Human, Monkey
Host Goat
Clonality Polyclonal
Calculated MW 530kDa
Dilution ELISA (1:16000), IHC-P (3.75 µg/ml),
Additional Information
Gene ID 57448
Other Names Baculoviral IAP repeat-containing protein 6, 6.3.2.-, BIR repeat-containing ubiquitin-conjugating enzyme, BRUCE, Ubiquitin-conjugating BIR domain enzyme apollon, APOLLON, BIRC6, KIAA1289
Target/Specificity Human BIRC6.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsBRUCE / BIRC6 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BIRC6
Synonyms KIAA1289
Function Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.
Cellular Location Golgi apparatus, trans-Golgi network membrane. Midbody. Endosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis
Tissue Location Expressed in brain cancer cells.
Research Areas
Citations (0)

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Background

Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.

References

Hillier L.W.,et al.Nature 434:724-731(2005).
Chen Z.,et al.Biochem. Biophys. Res. Commun. 264:847-854(1999).
Nagase T.,et al.DNA Res. 6:337-345(1999).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Qiu X.B.,et al.EMBO J. 23:800-810(2004).

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$ 395.00
Cat# ALS15353
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(40 western blots)
Availability: 5 days
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