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ESYT1 Antibody (Internal)

Goat Polyclonal Antibody

     
  • WB - ESYT1 Antibody (Internal) ALS15358
    Antibody (0.5 ug/ml) staining of Human Adipose lysate (35 ug protein in RIPA buffer).
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9BSJ8
Reactivity Human, Monkey
Host Goat
Clonality Polyclonal
Calculated MW 123kDa
Dilution ELISA (1:8000), IHC-P (3.75 µg/ml), WB (1-3 µg/ml)
Additional Information
Gene ID 23344
Other Names Extended synaptotagmin-1, E-Syt1, Membrane-bound C2 domain-containing protein, ESYT1, FAM62A, KIAA0747, MBC2
Target/Specificity Human ESYT1 / FAM62A.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsESYT1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ESYT1
Synonyms FAM62A, KIAA0747, MBC2
Function Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane.
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Peripheral membrane protein Note=Localizes primarily to the endoplasmic reticulum. Recruited to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Background

Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane.

References

Min S.-W.,et al.Proc. Natl. Acad. Sci. U.S.A. 104:3823-3828(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Nagase T.,et al.DNA Res. 5:277-286(1998).
Bienvenut W.V.,et al.Submitted (NOV-2005) to UniProtKB.

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$ 395.00
Cat# ALS15358
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