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CPT1C Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q8TCG5 |
| Reactivity | Human, Monkey, Horse, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 91kDa |
| Dilution | IHC-P (3.75 µg/ml), WB (1-3 µg/ml), |
| Gene ID | 126129 |
|---|---|
| Other Names | Carnitine O-palmitoyltransferase 1, brain isoform, CPT1-B, 2.3.1.21, CPT IC, Carnitine O-palmitoyltransferase I, brain isoform, CPTI-B, Carnitine palmitoyltransferase 1C, CPT1C, CATL1 |
| Target/Specificity | Human CPT1C. This antibody is expected to recognise both reported isoforms (NP_689572.1; NP_001129524.1). Reported variants represent identical protein (NP_001186681.1; NP_001186682.1; NP_689572.1). |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | CPT1C Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CPT1C (HGNC:18540) |
|---|---|
| Synonyms | CATL1 |
| Function | Palmitoyl thioesterase specifically expressed in the endoplasmic reticulum of neurons. Modulates the trafficking of the glutamate receptor, AMPAR, to plasma membrane through depalmitoylation of GRIA1 (PubMed:30135643). Also regulates AMPR trafficking through the regulation of SACM1L phosphatidylinositol-3-phosphatase activity by interaction in a malonyl-CoA dependent manner (By similarity). Binds malonyl-CoA and couples malonyl-CoA to ceramide levels, necessary for proper spine maturation and contributing to systemic energy homeostasis and appetite control (PubMed:16651524). Binds to palmitoyl-CoA, but does not have carnitine palmitoyltransferase 1 catalytic activity or at very low levels (PubMed:25751282, PubMed:30135643). |
| Cellular Location | Cell projection, dendrite. Cell projection, axon. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localized in the soma and dendritic and axonal projections. |
| Tissue Location | Expressed predominantly in brain and testis. Expressed in motor neurons. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Price N.,et al.Genomics 80:433-442(2002).
Scorilas A.,et al.Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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