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UNC5H3 / UNC5C Antibody (Internal)

Goat Polyclonal Antibody

     
  • WB - UNC5H3 / UNC5C Antibody (Internal) ALS15362
    UNC5C antibody (50 ug/ml) staining of islets in Mouse Pancreas.
  • IHC - UNC5H3 / UNC5C Antibody (Internal) ALS15362
    Anti-UNC5H3 / UNC5C antibody IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession O95185
Reactivity Human, Mouse, Rat, Hamster, Monkey
Host Goat
Clonality Polyclonal
Calculated MW 103kDa
Dilution ELISA (1:32000), IHC-P (3.75 µg/ml),
Additional Information
Gene ID 8633
Other Names Netrin receptor UNC5C, Protein unc-5 homolog 3, Protein unc-5 homolog C, UNC5C, UNC5H3
Target/Specificity Human UNC5C.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsUNC5H3 / UNC5C Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UNC5C
Synonyms UNC5H3
Function Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
Cellular Location Cell membrane {ECO:0000250|UniProtKB:O08747}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O08747}. Cell junction, synapse, synaptosome {ECO:0000250|UniProtKB:Q761X5}
Tissue Location Mainly expressed in brain. Also expressed in kidney. Not expressed in developing or adult lung
Research Areas
Citations (0)

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Background

Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).

References

Ackerman S.L.,et al.Genomics 52:205-208(1998).
Hillier L.W.,et al.Nature 434:724-731(2005).
Thiebault K.,et al.Proc. Natl. Acad. Sci. U.S.A. 100:4173-4178(2003).

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$ 395.00
Cat# ALS15362
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