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ACPP / PAP Antibody (Internal)

Goat Polyclonal Antibody

     
  • WB - ACPP / PAP Antibody (Internal) ALS15366
    ACPP antibody (0.3 ug/ml) staining of Human Prostate lysate (35 ug protein/ml in RIPA buffer).
  • IHC - ACPP / PAP Antibody (Internal) ALS15366
    Anti-ACPP antibody IHC of human prostate.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P15309
Reactivity Human, Mouse, Rat, Rabbit, Hamster, Monkey, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 45kDa
Dilution ELISA (1:64000), IHC-P (3.75 µg/ml), WB (0.3-1 µg/ml)
Additional Information
Gene ID 55
Other Names Prostatic acid phosphatase, PAP, 3.1.3.2, 5'-nucleotidase, 5'-NT, 3.1.3.5, Ecto-5'-nucleotidase, Thiamine monophosphatase, TMPase, PAPf39, ACPP
Target/Specificity Human ACPP. This antibody is expected to recognize both isoforms (NP_001090.2; NP_001127666.1).
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsACPP / PAP Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ACPP
Function A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.
Cellular Location Isoform 1: Secreted
Tissue Location Highly expressed in the prostate, restricted to glandular and ductal epithelial cells. Also expressed in bladder, kidney, pancreas, lung, cervix, testis and ovary. Weak expression in a subset of pancreatic islet cells, squamous epithelia, the pilosebaceous unit, colonic neuroendocrine cells and skin adnexal structures. Isoform 2 also expressed in the sarcolemma of skeletal muscle. Levels of this cellular isoform decreased in prostate cancer.
Research Areas
Citations (0)

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Background

A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.

References

Sharief F.S.,et al.Biochem. Biophys. Res. Commun. 184:1468-1476(1992).
van Etten R.L.,et al.J. Biol. Chem. 266:2313-2319(1991).
Sharief F.S.,et al.Biochem. Biophys. Res. Commun. 160:79-86(1989).
Vihko P.,et al.FEBS Lett. 236:275-281(1988).
Tailor P.G.,et al.Nucleic Acids Res. 18:4928-4928(1990).

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$ 395.00
Cat# ALS15366
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