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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   SOX3 Antibody (C-Terminus)   

SOX3 Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • WB - SOX3 Antibody (C-Terminus) ALS15377
    SOX3 antibody (0.5 ug/ml) staining of Human Cerebral Cortex lysate (35 ug protein/ml in RIPA buffer).
  • IHC - SOX3 Antibody (C-Terminus) ALS15377
    Anti-SOX3 antibody IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P41225
Reactivity Human, Mouse, Rabbit, Monkey
Host Goat
Clonality Polyclonal
Calculated MW 45kDa
Dilution ELISA (1:8000), IHC-P (3.75 µg/ml), WB (0.5-1.5 µg/ml)
Additional Information
Gene ID 6658
Other Names Transcription factor SOX-3, SOX3
Target/Specificity Human SOX3.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsSOX3 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SOX3
Function Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity).
Cellular Location Nucleus.
Research Areas
Citations (0)

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Background

Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity).

References

Stevanovic M.,et al.Hum. Mol. Genet. 2:2013-2018(1993).
Gorry M.C.,et al.Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
Ross M.T.,et al.Nature 434:325-337(2005).
Denny P.,et al.Nucleic Acids Res. 20:2887-2887(1992).
Sutton E.,et al.J. Clin. Invest. 121:328-341(2011).

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$ 395.00
Cat# ALS15377
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