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GRM2 / MGLUR2 Antibody (Internal)

Goat Polyclonal Antibody

     
  • WB - GRM2 / MGLUR2 Antibody (Internal) ALS15381
    GRM2 antibody (1 ug/ml) staining of Human Hippocampus lysate (35 ug protein/ml in RIPA buffer).
    detail
  • IHC - GRM2 / MGLUR2 Antibody (Internal) ALS15381
    Anti-MGLUR2 / GLUR2 antibody IHC of human brain, cortex.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q14416
Reactivity Human, Mouse, Rat, Rabbit, Hamster, Monkey, Horse, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 96kDa
Dilution ELISA (1:16000), IHC-P (3.75 µg/ml), WB (1-3 µg/ml)
Additional Information
Gene ID 2912
Other Names Metabotropic glutamate receptor 2, mGluR2, GRM2, GPRC1B, MGLUR2
Target/Specificity Human GRM2 / MGLUR2. This antibody is expected to recognize both isoforms (NP_000830.2; NP_001123535.1).
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsGRM2 / MGLUR2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRM2 (HGNC:4594)
Synonyms GPRC1B, MGLUR2
Function G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
Cellular Location Cell membrane; Multi-pass membrane protein. Synapse. Cell projection, dendrite
Tissue Location Detected in brain cortex (at protein level). Widely expressed in different regions of the adult brain as well as in fetal brain.
Research Areas
Citations (0)
citation

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Background

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.

References

Flor P.J.,et al.Eur. J. Neurosci. 7:622-629(1995).
Yasuyuki F.,et al.Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
Bonner T.I.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Kaighin V.A.,et al.Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# ALS15381
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