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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   CIRP / CIRBP Antibody (aa161-172)   

CIRP / CIRBP Antibody (aa161-172)

Goat Polyclonal Antibody

     
  • WB - CIRP / CIRBP Antibody (aa161-172) ALS15385
    CIRBP antibody (0.01 ug/ml) staining of Mouse Testis lysate (35 ug protein/ml in RIPA buffer).
  • IHC - CIRP / CIRBP Antibody (aa161-172) ALS15385
    Anti-CIRP / CIRBP antibody IHC of human testis.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q14011
Reactivity Human, Mouse, Rat, Hamster, Monkey, Pig, Dog
Host Goat
Clonality Polyclonal
Calculated MW 19kDa
Dilution ELISA (1:32000), IHC-P (3.75 µg/ml), WB (0.01-0.03 µg/ml)
Additional Information
Gene ID 1153
Other Names Cold-inducible RNA-binding protein, A18 hnRNP, Glycine-rich RNA-binding protein CIRP, CIRBP, A18HNRNP, CIRP
Target/Specificity Human CIRBP.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsCIRP / CIRBP Antibody (aa161-172) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CIRBP
Synonyms A18HNRNP, CIRP
Function Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold- induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.
Cellular Location Nucleus, nucleoplasm. Cytoplasm. Note=Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity).
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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Background

Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold- induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.

References

Nishiyama H.,et al.Gene 204:115-120(1997).
Sheikh M.S.,et al.J. Biol. Chem. 272:26720-26726(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
Yang C.,et al.J. Biol. Chem. 276:47277-47284(2001).

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$ 395.00
Cat# ALS15385
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