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SEPT4 / Septin 4 Antibody (Internal)

Goat Polyclonal Antibody

     
  • WB - SEPT4 / Septin 4 Antibody (Internal) ALS15388
    SEPT4 antibody (1 ug/ml) staining of Human Heart lysate (35 ug protein/ml in RIPA buffer).
  • IHC - SEPT4 / Septin 4 Antibody (Internal) ALS15388
    Anti-SEPT4 / Septin-4 antibody IHC of human brain, cerebellum.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O43236
Reactivity Human, Rat, Rabbit, Zebrafish, Hamster, Pig, Horse, Xenopus, Dog
Host Goat
Clonality Polyclonal
Calculated MW 55kDa
Dilution ELISA (1:64000), IHC-P (3.75 µg/ml), WB (1-3 µg/ml)
Additional Information
Gene ID 5414
Other Names Septin-4, Apoptosis-related protein in the TGF-beta signaling pathway, ARTS, Bradeion beta, Brain protein H5, CE5B3 beta, Cell division control-related protein 2, hCDCREL-2, Cerebral protein 7, Peanut-like protein 2, SEPT4, ARTS, PNUTL2, SEP4
Target/Specificity Human SEPT4 / Septin 4. This antibody is expected to recognize isoform 1 (NP_004565.1), 3 (NP_536341.1) and 4 (NP_001185642.1). Amino acid numbering in name refers to NP_004565.1 sequence.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsSEPT4 / Septin 4 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SEPT4
Synonyms ARTS, PNUTL2, SEP4
Function Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli.
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton. Note=In platelets, found in areas surrounding alpha-granules.
Tissue Location Widely expressed in adult and fetal tissues with highest expression in adult brain (at protein level), heart, liver and adrenal gland and fetal heart, kidney, liver and lung Also expressed in colorectal cancers and malignant melanomas Expressed in platelets.
Research Areas
Citations (0)

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Background

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli.

References

Paavola P.,et al.Genomics 55:122-125(1999).
Zieger B.,et al.Gene 261:197-203(2000).
Larisch S.,et al.Nat. Cell Biol. 2:915-921(2000).
Tanaka M.,et al.Biochem. Biophys. Res. Commun. 286:547-553(2001).
Yoshimoto M.,et al.Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS15388
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