|Application ||WB, IHC-P, E|
|Reactivity||Human, Rat, Rabbit, Zebrafish, Hamster, Pig, Horse, Xenopus, Dog|
|Dilution||ELISA (1:64000), IHC-P (3.75 µg/ml), WB (1-3 µg/ml)|
|Other Names||Septin-4, Apoptosis-related protein in the TGF-beta signaling pathway, ARTS, Bradeion beta, Brain protein H5, CE5B3 beta, Cell division control-related protein 2, hCDCREL-2, Cerebral protein 7, Peanut-like protein 2, SEPT4, ARTS, PNUTL2, SEP4|
|Target/Specificity||Human SEPT4 / Septin 4. This antibody is expected to recognize isoform 1 (NP_004565.1), 3 (NP_536341.1) and 4 (NP_001185642.1). Amino acid numbering in name refers to NP_004565.1 sequence.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||SEPT4 / Septin 4 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ARTS, PNUTL2, SEP4|
|Function||Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Note=In platelets, found in areas surrounding alpha-granules.|
|Tissue Location||Widely expressed in adult and fetal tissues with highest expression in adult brain (at protein level), heart, liver and adrenal gland and fetal heart, kidney, liver and lung Also expressed in colorectal cancers and malignant melanomas Expressed in platelets.|
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Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli.
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Zieger B.,et al.Gene 261:197-203(2000).
Larisch S.,et al.Nat. Cell Biol. 2:915-921(2000).
Tanaka M.,et al.Biochem. Biophys. Res. Commun. 286:547-553(2001).
Yoshimoto M.,et al.Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
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