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AES / Groucho Antibody (N-Terminus)

Goat Polyclonal Antibody

     
  • WB - AES / Groucho Antibody (N-Terminus) ALS15403
    AES antibody (0.3 ug/ml) staining of Human Cerebral Cortex lysate (35 ug protein/ml in RIPA buffer).
  • IHC - AES / Groucho Antibody (N-Terminus) ALS15403
    Anti-Groucho antibody IHC of human colon, submucosal plexus.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q08117
Reactivity Human, Mouse, Rat, Hamster, Xenopus, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 22kDa
Dilution ELISA (1:64000), IHC-P (3.75 µg/ml), WB (0.3-1 µg/ml)
Additional Information
Gene ID 166
Other Names Amino-terminal enhancer of split, Amino enhancer of split, Gp130-associated protein GAM, Grg-5, Groucho-related protein 5, Protein ESP1, Protein GRG, AES, GRG, GRG5
Target/Specificity Human AES / GRG / Groucho. This antibody is expected to recognize all reported isoforms (NP_945320.1; NP_001121.2; NP_945321.1).
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsAES / Groucho Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AES
Synonyms GRG, GRG5
Function Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.
Cellular Location Nucleus.
Tissue Location Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver
Research Areas
Citations (0)

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Background

Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.

References

Scala L.A.,et al.Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases.
Hou E.W.,et al.DNA Cell Biol. 17:911-913(1998).
Liu Y.,et al.Zhonghua Wei Sheng Wu Xue He Mian Yi Xue Za Zhi 18:106-110(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).

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$ 395.00
Cat# ALS15403
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