|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:32000), IHC-P (3.75 µg/ml), WB (1-3 µg/ml)|
|Other Names||Neuronal acetylcholine receptor subunit alpha-5, CHRNA5, NACHRA5|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||CHRNA5 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Chini B.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:1572-1576(1992).
Elliott K.J.,et al.J. Mol. Neurosci. 7:217-228(1996).
Groot Kormelink P.J.,et al.FEBS Lett. 400:309-314(1997).
Duga S.,et al.Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
Chanock S.J.,et al.Nature 452:537-538(2008).
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