|Application ||WB, IHC-P, IF, E|
|Dilution||ELISA (1:40000), IF (1:100-1:500), IHC-P (5 µg/ml), WB (1:500-1:1000) ,|
|Other Names||Separin, 22.214.171.124, Caspase-like protein ESPL1, Extra spindle poles-like 1 protein, Separase, ESPL1, ESP1, KIAA0165|
|Target/Specificity||SEPARASE (Ab-801) Antibody detects endogenous levels of total SEPARASE protein.|
|Reconstitution & Storage||Store at -20°C for up to one year.|
|Precautions||ESPL1 / Separase Antibody (aa767-816) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.|
|Cellular Location||Cytoplasm. Nucleus.|
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Provided below are standard protocols that you may find useful for product applications.
Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.
Waizenegger I.,et al.Curr. Biol. 12:1368-1378(2002).
Nagase T.,et al.DNA Res. 3:17-24(1996).
Scherer S.E.,et al.Nature 440:346-351(2006).
Zou H.,et al.Science 285:418-422(1999).
Stemmann O.,et al.Cell 107:715-726(2001).
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