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ESPL1 / Separase Antibody (aa767-816)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | Q14674 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 233kDa |
| Dilution | ELISA (1:40000), IF (1:100-1:500), IHC-P (5 µg/ml), WB (1:500-1:1000) , |
| Gene ID | 9700 |
|---|---|
| Other Names | Separin, 3.4.22.49, Caspase-like protein ESPL1, Extra spindle poles-like 1 protein, Separase, ESPL1, ESP1, KIAA0165 |
| Target/Specificity | SEPARASE (Ab-801) Antibody detects endogenous levels of total SEPARASE protein. |
| Reconstitution & Storage | Store at -20°C for up to one year. |
| Precautions | ESPL1 / Separase Antibody (aa767-816) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ESPL1 |
|---|---|
| Synonyms | ESP1, KIAA0165 |
| Function | Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. |
| Cellular Location | Cytoplasm. Nucleus. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.
References
Waizenegger I.,et al.Curr. Biol. 12:1368-1378(2002).
Nagase T.,et al.DNA Res. 3:17-24(1996).
Scherer S.E.,et al.Nature 440:346-351(2006).
Zou H.,et al.Science 285:418-422(1999).
Stemmann O.,et al.Cell 107:715-726(2001).
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