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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   ESPL1 / Separase Antibody (aa767-816)   

ESPL1 / Separase Antibody (aa767-816)

Rabbit Polyclonal Antibody

     
  • IF - ESPL1 / Separase Antibody (aa767-816) ALS15407
    Immunofluorescence of HUVEC cells, using SEPARASE (Ab-801) Antibody.
  • IHC - ESPL1 / Separase Antibody (aa767-816) ALS15407
    Anti-Separase antibody IHC of human skin.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q14674
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 233kDa
Dilution ELISA (1:40000), IF (1:100-1:500), IHC-P (5 µg/ml), WB (1:500-1:1000) ,
Additional Information
Gene ID 9700
Other Names Separin, 3.4.22.49, Caspase-like protein ESPL1, Extra spindle poles-like 1 protein, Separase, ESPL1, ESP1, KIAA0165
Target/Specificity SEPARASE (Ab-801) Antibody detects endogenous levels of total SEPARASE protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsESPL1 / Separase Antibody (aa767-816) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ESPL1
Synonyms ESP1, KIAA0165
Function Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.
Cellular Location Cytoplasm. Nucleus.
Volume 50 µl
Research Areas
Citations (0)

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Background

Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.

References

Waizenegger I.,et al.Curr. Biol. 12:1368-1378(2002).
Nagase T.,et al.DNA Res. 3:17-24(1996).
Scherer S.E.,et al.Nature 440:346-351(2006).
Zou H.,et al.Science 285:418-422(1999).
Stemmann O.,et al.Cell 107:715-726(2001).

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$ 395.00
Cat# ALS15407
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