PBK / TOPK Antibody (aa1-50)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q96KB5 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 36kDa |
Dilution | ELISA (1:1000), IHC-P (5 µg/ml), WB (1:500-1:1000) |
Gene ID | 55872 |
---|---|
Other Names | Lymphokine-activated killer T-cell-originated protein kinase, 2.7.12.2, Cancer/testis antigen 84, CT84, MAPKK-like protein kinase, Nori-3, PDZ-binding kinase, Spermatogenesis-related protein kinase, SPK, T-LAK cell-originated protein kinase, PBK, TOPK |
Target/Specificity | PBK/TOPK (Ab-9) Antibody detects endogenous levels of total PBK/TOPK protein. |
Reconstitution & Storage | Store at -20°C for up to one year. |
Precautions | PBK / TOPK Antibody (aa1-50) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PBK |
---|---|
Synonyms | TOPK |
Function | Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin- induced DNA damage. |
Tissue Location | Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules. |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.
References
Abe Y.,et al.J. Biol. Chem. 275:21525-21531(2000).
Gaudet S.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:5167-5172(2000).
Zhao S.,et al.Int. J. Biochem. Cell Biol. 33:631-636(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 439:331-335(2006).
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