|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:1000), IHC-P (5 µg/ml), WB (1:500-1:1000)|
|Other Names||Lymphokine-activated killer T-cell-originated protein kinase, 22.214.171.124, Cancer/testis antigen 84, CT84, MAPKK-like protein kinase, Nori-3, PDZ-binding kinase, Spermatogenesis-related protein kinase, SPK, T-LAK cell-originated protein kinase, PBK, TOPK|
|Target/Specificity||PBK/TOPK (Ab-9) Antibody detects endogenous levels of total PBK/TOPK protein.|
|Reconstitution & Storage||Store at -20°C for up to one year.|
|Precautions||PBK / TOPK Antibody (aa1-50) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.|
|Tissue Location||Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.
Abe Y.,et al.J. Biol. Chem. 275:21525-21531(2000).
Gaudet S.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:5167-5172(2000).
Zhao S.,et al.Int. J. Biochem. Cell Biol. 33:631-636(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 439:331-335(2006).
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