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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PBK / TOPK Antibody (aa1-50)   

PBK / TOPK Antibody (aa1-50)

Rabbit Polyclonal Antibody

     
  • WB - PBK / TOPK Antibody (aa1-50) ALS15410
    Western blot of extracts from COS7 cells, treated with Nocodazole 1 ug/ml 16h, using PBK/TOPK...
    detail
  • IHC - PBK / TOPK Antibody (aa1-50) ALS15410
    Anti-PBK / TOPK antibody IHC of human thymus.
    detail
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q96KB5
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 36kDa
Dilution ELISA (1:1000), IHC-P (5 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 55872
Other Names Lymphokine-activated killer T-cell-originated protein kinase, 2.7.12.2, Cancer/testis antigen 84, CT84, MAPKK-like protein kinase, Nori-3, PDZ-binding kinase, Spermatogenesis-related protein kinase, SPK, T-LAK cell-originated protein kinase, PBK, TOPK
Target/Specificity PBK/TOPK (Ab-9) Antibody detects endogenous levels of total PBK/TOPK protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsPBK / TOPK Antibody (aa1-50) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PBK
Synonyms TOPK
Function Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin- induced DNA damage.
Tissue Location Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules.
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.

References

Abe Y.,et al.J. Biol. Chem. 275:21525-21531(2000).
Gaudet S.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:5167-5172(2000).
Zhao S.,et al.Int. J. Biochem. Cell Biol. 33:631-636(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 439:331-335(2006).

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Discontinued
Cat# ALS15410
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