|Application ||WB, IHC-P, E|
|Other Accession||O95782, O94973, P63010, Q92481|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||48062 Da|
|Dilution||ELISA (1:10000), IHC-P (5 µg/ml), WB (1:500-1:1000)|
|Other Names||Transcription factor AP-2-alpha, AP2-alpha, AP-2 transcription factor, Activating enhancer-binding protein 2-alpha, Activator protein 2, AP-2, TFAP2A, AP2TF, TFAP2|
|Target/Specificity||AP-2 Antibody detects endogenous levels of total AP-2 protein.|
|Reconstitution & Storage||Store at -20°C for up to one year.|
|Precautions||AP-2 Alpha/Beta Antibody (aa388-437) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.|
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