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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   MCM3AP / GANP Antibody (aa1841-1890)   

MCM3AP / GANP Antibody (aa1841-1890)

Rabbit Polyclonal Antibody

     
  • WB - MCM3AP / GANP Antibody (aa1841-1890) ALS15422
    Western blot of extracts from COS7 cells, using GANP Antibody.
  • IHC - MCM3AP / GANP Antibody (aa1841-1890) ALS15422
    Anti-MCM3AP antibody IHC of human placenta.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O60318
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 218kDa
Dilution ELISA (1:5000), IHC-P (5 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 8888
Other Names Germinal-center associated nuclear protein, GANP, 80 kDa MCM3-associated protein, MCM3 acetylating protein, MCM3AP, 2.3.1.-, MCM3 acetyltransferase, MCM3AP, GANP, KIAA0572, MAP80
Target/Specificity GANP Antibody detects endogenous levels of total GANP protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsMCM3AP / GANP Antibody (aa1841-1890) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MCM3AP
Synonyms GANP, KIAA0572, MAP80
Function Isoform GANP: Essential for the generation of high- affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation- dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells (By similarity). Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
Cellular Location Isoform GANP: Cytoplasm. Nucleus envelope. Nucleus, nuclear pore complex. Note=In B-cells nuclear import depends on interaction with AICDA/AID, and GANP is selectively targeted to the IgV-region gene.
Volume 50 µl
Research Areas
Citations (0)

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Background

Isoform GANP: Essential for the generation of high- affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation- dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells (By similarity). Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.

References

Abe E.,et al.Gene 255:219-227(2000).
Hattori M.,et al.Nature 405:311-319(2000).
Nagase T.,et al.DNA Res. 5:31-39(1998).
Takei Y.,et al.J. Biol. Chem. 273:22177-22180(1998).
Takei Y.,et al.EMBO Rep. 2:119-123(2001).

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$ 395.00
Cat# ALS15422
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