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TRADD Antibody (aa251-300)

Rabbit Polyclonal Antibody

     
  • WB - TRADD Antibody (aa251-300) ALS15431
    Western blot of extracts from COS7 cells, using TRADD Antibody.
  • IHC - TRADD Antibody (aa251-300) ALS15431
    Anti-TRADD antibody IHC of human lung.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q15628
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 34kDa
Dilution ELISA (1:5000), IHC-P (5 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 8717
Other Names Tumor necrosis factor receptor type 1-associated DEATH domain protein, TNFR1-associated DEATH domain protein, TNFRSF1A-associated via death domain, TRADD
Target/Specificity TRADD Antibody detects endogenous levels of total TRADD protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsTRADD Antibody (aa251-300) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRADD
Function The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.
Cellular Location Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Shuttles between the cytoplasm and the nucleus.
Tissue Location Found in all examined tissues.
Volume 50 µl
Research Areas
Citations (0)

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Background

The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.

References

Hsu H.,et al.Cell 81:495-504(1995).
Scheuerpflug C.G.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Kaiser C.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS15431
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