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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LRAT Antibody (aa111-160)   

LRAT Antibody (aa111-160)

Rabbit Polyclonal Antibody

     
  • IF - LRAT Antibody (aa111-160) ALS15433
    Immunofluorescence of HUVEC cells, using LRAT Antibody.
  • WB - LRAT Antibody (aa111-160) ALS15433
    Western blot of extracts from COLO205 cells, using LRAT Antibody.
  • IHC - LRAT Antibody (aa111-160) ALS15433
    Anti-LRAT antibody IHC of human tonsil.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession O95237
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 26kDa
Dilution ELISA (1:10000), IF (1:100-1:500), IHC-P (5 µg/ml), WB (1:500-1:1000) ,
Additional Information
Gene ID 9227
Other Names Lecithin retinol acyltransferase, 2.3.1.135, Phosphatidylcholine--retinol O-acyltransferase, LRAT
Target/Specificity LRAT Antibody detects endogenous levels of total LRAT protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsLRAT Antibody (aa111-160) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LRAT
Function Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments.
Cellular Location Endoplasmic reticulum membrane; Single-pass membrane protein. Rough endoplasmic reticulum. Endosome, multivesicular body. Cytoplasm, perinuclear region Note=Present in the rough endoplasmic reticulum and multivesicular body in hepatic stellate cells. Present in the rough endoplasmic reticulum and perinuclear region in endothelial cells (By similarity).
Tissue Location Hepatic stellate cells and endothelial cells (at protein level). Found at high levels in testis and liver, followed by retinal pigment epithelium, small intestine, prostate, pancreas and colon. Low expression observed in brain. In fetal tissues, expressed in retinal pigment epithelium and liver, and barely in the brain.
Volume 50 µl
Research Areas
Citations (0)

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Background

Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments.

References

Ruiz A.,et al.J. Biol. Chem. 274:3834-3841(1999).
Zolfaghari R.,et al.Gene 341:181-188(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Mondal M.S.,et al.Biochemistry 39:5215-5220(2000).

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$ 395.00
Cat# ALS15433
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