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HEXB Antibody (aa481-530)

Rabbit Polyclonal Antibody

     
  • WB - HEXB Antibody (aa481-530) ALS15436
    Western blot of extracts from Jurkat cells, using HEXB Antibody.
    detail
  • IHC - HEXB Antibody (aa481-530) ALS15436
    Anti-HEXB antibody IHC of human brain, cortex.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P07686
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 63kDa
Dilution ELISA (1:20000), IHC-P (5 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 3074
Other Names Beta-hexosaminidase subunit beta, 3.2.1.52, Beta-N-acetylhexosaminidase subunit beta, Hexosaminidase subunit B, Cervical cancer proto-oncogene 7 protein, HCC-7, N-acetyl-beta-glucosaminidase subunit beta, Beta-hexosaminidase subunit beta chain B, Beta-hexosaminidase subunit beta chain A, HEXB
Target/Specificity HEXB Antibody detects endogenous levels of total HEXB protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsHEXB Antibody (aa481-530) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HEXB (HGNC:4879)
Function Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides (PubMed:11707436, PubMed:9694901, PubMed:8672428, PubMed:8123671). The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide (PubMed:11707436). Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A (PubMed:9694901, PubMed:8672428, PubMed:8123671). During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida (By similarity).
Cellular Location Lysosome. Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000250|UniProtKB:P20060}
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues.

References

Korneluk R.G.,et al.J. Biol. Chem. 261:8407-8413(1986).
Neote K.,et al.Genomics 3:279-286(1988).
Proia R.L.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:1883-1887(1988).
Kim J.W.,et al.Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.

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$ 467.50
Cat# ALS15436
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