TRIM59 Antibody (aa191-240)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
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Primary Accession | Q8IWR1 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 47kDa |
Dilution | ELISA (1:5000), IF (1:100-1:500), IHC-P (5 µg/ml), WB (1:500-1:1000) , |
Gene ID | 286827 |
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Other Names | Tripartite motif-containing protein 59, RING finger protein 104, Tumor suppressor TSBF-1, TRIM59, RNF104, TRIM57, TSBF1 |
Target/Specificity | TRIM59 Antibody detects endogenous levels of total TRIM59 protein. |
Reconstitution & Storage | Store at -20°C for up to one year. |
Precautions | TRIM59 Antibody (aa191-240) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TRIM59 |
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Synonyms | RNF104, TRIM57, TSBF1 |
Function | E3 ubiquitin ligase involved in different processes such as development and immune response (PubMed:22588174, PubMed:30231667). Serves as a negative regulator for innate immune signaling pathways by suppressing RLR-induced activation of IRF3/7 and NF-kappa-B via interaction with adapter ECSIT (PubMed:22588174). Regulates autophagy through modulating both the transcription and the ubiquitination of BECN1 (PubMed:30231667). On the one hand, regulates the transcription of BECN1 through negatively modulating the NF-kappa-B pathway. On the other hand, regulates TRAF6-mediated 'Lys-63'-linked ubiquitination of BECN1, thus affecting the formation of the BECN1-PIK3C3 complex. In addition, mediates 'Lys-48'-linked ubiquitination of TRAF6 and thereby promotes TRAF6 proteasomal degradation (PubMed:30231667). Acts also as a critical regulator for early embryo development from blastocyst stage to gastrula through modulating F-actin assembly and WASH1 'Lys-63'- linked ubiquitination (By similarity). |
Cellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
References
Gong L.,et al.Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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