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>   home   >   Products   >   Primary Antibodies   >   SETD7 / SET7 Antibody (clone 5B4)   

SETD7 / SET7 Antibody (clone 5B4)

Mouse Monoclonal Antibody

     
  • WB - SETD7 / SET7 Antibody (clone 5B4) ALS15464
    SET7 monoclonal antibody (M01), clone 5B4 Western blot of SET7 expression in Jurkat.
  • IF - SETD7 / SET7 Antibody (clone 5B4) ALS15464
    Immunofluorescence of monoclonal antibody to SET7 on HeLa cell. [antibody concentration 10 ug/ml]
  • IHC - SETD7 / SET7 Antibody (clone 5B4) ALS15464
    Anti-SETD7 / SET7 antibody IHC of human skin.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q8WTS6
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 5B4
Calculated MW 41kDa
Dilution IF (10 µg/ml), IHC-P (5 µg/ml),
Additional Information
Gene ID 80854
Other Names Histone-lysine N-methyltransferase SETD7, 2.1.1.43, Histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, Lysine N-methyltransferase 7, SET domain-containing protein 7, SET7/9, SETD7, KIAA1717, KMT7, SET7, SET9
Target/Specificity Human SET7
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsSETD7 / SET7 Antibody (clone 5B4) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SETD7
Synonyms KIAA1717, KMT7, SET7, SET9
Function Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
Cellular Location Nucleus. Chromosome.
Tissue Location Widely expressed. Expressed in pancreatic islets
Volume 50 µl
Citations (0)

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Background

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

References

Wang H.,et al.Mol. Cell 8:1207-1217(2001).
Nishioka K.,et al.Genes Dev. 16:479-489(2002).
Hillier L.W.,et al.Nature 434:724-731(2005).
Nagase T.,et al.DNA Res. 7:347-355(2000).
Martens J.H.,et al.Mol. Cell. Biol. 23:1808-1816(2003).

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$ 450.00
Cat# ALS15464
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