|Application ||IHC-P, E|
|Dilution||ELISA (1:100-1:1000), IHC-P (1:50),|
|Other Names||Hepatitis A virus cellular receptor 2, HAVcr-2, T-cell immunoglobulin and mucin domain-containing protein 3, TIMD-3, T-cell immunoglobulin mucin receptor 3, TIM-3, T-cell membrane protein 3, HAVCR2, TIM3, TIMD3|
|Target/Specificity||Human HAVCR2 / TIM 3|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||HAVCR2 / TIM-3 Antibody (aa176-194) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||T-helper type 1 lymphocyte (Th1)-specific.|
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Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9.
Monney L.,et al.Nature 415:536-541(2002).
Zhang W.,et al.Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
Kuehn E.W.,et al.Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
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