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GBP4 / Mpa2 Antibody (aa551-600)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q96PP9 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 73kDa |
| Dilution | ELISA (1:40000), IHC-P (5 µg/ml), |
| Gene ID | 115361 |
|---|---|
| Other Names | Guanylate-binding protein 4, GTP-binding protein 4, GBP-4, Guanine nucleotide-binding protein 4, GBP4 |
| Target/Specificity | GBP4 Antibody detects endogenous levels of total GBP4 protein. |
| Reconstitution & Storage | Store at -20°C for up to one year. |
| Precautions | GBP4 / Mpa2 Antibody (aa551-600) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GBP4 {ECO:0000303|Ref.1, ECO:0000312|HGNC:HGNC:20480} |
|---|---|
| Function | Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (By similarity). Negatively regulates the antiviral response by inhibiting activation of IRF7 transcription factor (By similarity). |
| Cellular Location | Golgi apparatus membrane. Cytoplasm Nucleus. Cytoplasm, perinuclear region. Note=Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP5, at the Golgi apparatus. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity).
References
Avdalovic A.,et al.Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Jikuya H.,et al.DNA Res. 10:49-57(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Tripal P.,et al.J. Interferon Cytokine Res. 27:44-52(2007).
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