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MPRIP / RIP3 Antibody (aa723-772)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q6WCQ1 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 117kDa |
| Dilution | ELISA (1:40000), IHC-P (5 µg/ml), |
| Gene ID | 23164 |
|---|---|
| Other Names | Myosin phosphatase Rho-interacting protein, M-RIP, Rho-interacting protein 3, RIP3, p116Rip, MPRIP |
| Target/Specificity | MPRIP Antibody detects endogenous levels of total MPRIP protein. |
| Reconstitution & Storage | Store at -20°C for up to one year. |
| Precautions | MPRIP / RIP3 Antibody (aa723-772) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MPRIP |
|---|---|
| Synonyms | KIAA0864, MRIP, RHOIP3 {ECO:0000312|EMBL |
| Function | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin- binding region leads to disassembly of stress fibers in neuronal cells. |
| Cellular Location | Cytoplasm, cytoskeleton Note=Colocalizes with F-actin |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F- actin-binding region leads to disassembly of stress fibers in neuronal cells.
References
Surks H.K.,et al.J. Biol. Chem. 278:51484-51493(2003).
Koga Y.,et al.J. Biol. Chem. 280:4983-4991(2005).
Inazawa J.,et al.Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
Zody M.C.,et al.Nature 440:1045-1049(2006).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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