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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MPRIP / RIP3 Antibody (aa723-772)   

MPRIP / RIP3 Antibody (aa723-772)

Rabbit Polyclonal Antibody

     
  • IHC - MPRIP / RIP3 Antibody (aa723-772) ALS15504
    Anti-MPRIP / RIP3 antibody IHC of human heart.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession Q6WCQ1
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 117kDa
Dilution ELISA (1:40000), IHC-P (5 µg/ml),
Additional Information
Gene ID 23164
Other Names Myosin phosphatase Rho-interacting protein, M-RIP, Rho-interacting protein 3, RIP3, p116Rip, MPRIP
Target/Specificity MPRIP Antibody detects endogenous levels of total MPRIP protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsMPRIP / RIP3 Antibody (aa723-772) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MPRIP
Function Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F- actin-binding region leads to disassembly of stress fibers in neuronal cells.
Cellular Location Cytoplasm, cytoskeleton Note=Colocalizes with F-actin
Volume 50 µl
Research Areas
Citations (0)

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Background

Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F- actin-binding region leads to disassembly of stress fibers in neuronal cells.

References

Surks H.K.,et al.J. Biol. Chem. 278:51484-51493(2003).
Koga Y.,et al.J. Biol. Chem. 280:4983-4991(2005).
Inazawa J.,et al.Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
Zody M.C.,et al.Nature 440:1045-1049(2006).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).

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$ 395.00
Cat# ALS15504
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