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LONP2 / LONP Antibody (aa780-829)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q86WA8 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 95kDa |
| Dilution | ELISA (1:40000), IHC-P (5 µg/ml), |
| Gene ID | 83752 |
|---|---|
| Other Names | Lon protease homolog 2, peroxisomal {ECO:0000255|HAMAP-Rule:MF_03121}, 3.4.21.- {ECO:0000255|HAMAP-Rule:MF_03121}, Lon protease-like protein 2 {ECO:0000255|HAMAP-Rule:MF_03121}, Lon protease 2 {ECO:0000255|HAMAP-Rule:MF_03121}, Peroxisomal Lon protease {ECO:0000255|HAMAP-Rule:MF_03121}, LONP2 {ECO:0000255|HAMAP-Rule:MF_03121}, LONP |
| Target/Specificity | LONP2 Antibody detects endogenous levels of total LONP2 protein. |
| Reconstitution & Storage | Store at -20°C for up to one year. |
| Precautions | LONP2 / LONP Antibody (aa780-829) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LONP2 {ECO:0000255|HAMAP-Rule:MF_03121} |
|---|---|
| Synonyms | LONP |
| Function | ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. |
| Cellular Location | Peroxisome matrix {ECO:0000255|HAMAP- Rule:MF_03121, ECO:0000269|PubMed:14561759, ECO:0000269|PubMed:18281296, ECO:0000269|PubMed:22002062} |
| Tissue Location | Widely expressed, with high levels in the liver, kidney and pancreas. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.
References
De Walque S.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Kikuchi M.,et al.J. Biol. Chem. 279:421-428(2004).
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